Medically reregarded by Darren Hein, PharmD — Written by College of Illinois — Updated on September 2, 2018


Mucinex and also Nyquil Cold & Flu are two widespread, over-the-respond to remedies you have the right to find on your pharmacist’s shelf. Compare the symptoms that each drug treats as well as their side results, interactions, and warnings to watch if one is a better choice for you.

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The main differences in between these drugs are their energetic ingredients and exactly how those work-related to treat your symptoms.

Mucinex treats chest congestion. The primary energetic ingredient is an expectorant referred to as guaifenesin. It works by thinning the consistency of mucus in your air passeras. This loosens up mucus in your chest so you deserve to cough it up and out.

NyQuil temporarily treats common cold and also flu symptoms such as fever before, cough, nasal congestion, minor aches and also pains, headache, and also runny nose and also sneezing. The active ingredients are acetaminophen, dextromethorphan, and also doxylamine. These ingredients each occupational a small in a different way.

For instance, acetaminophen is a pain reliever and fever before reducer. It transforms the method your body senses pain and regulates temperature. Dextromethorphan suppresses the signals in your brain that create your coughing reflex. Doxylamine, on the other hand also, blocks a substance in your body called histamine. This substance reasons allergy symptoms such as itchy, watery eyes, runny nose, and itchy nose or throat. Together, these ingredients administer the relief you deserve to get from NyQuil.

The following table summarizes the differences in between Mucinex and also NyQuil at a glance.

Active ingredient(s)guaifenesinacetaminophen, dextromethorphan, doxylamine
Symptom(s) treatedchest congestionfever before, cough, nasal congestion, minor aches and also pains, headache, sore throat, runny nose, sneezing
Usagethroughout the dayat night
Formsextended-release dental tablet*, oral granulesoral liquid capsule, dental solution
Risk of interactionsnoyes
Risk of major side effectsnoyes

*There is also an extra-strength form of this tablet, which has twice as much of the energetic ingredient.

Forms and dosage

You deserve to use Mucinex throughout the day, however you commonly use NyQuil at night to assist you sleep and let your body recoup. The ingredient doxylamine in NyQuil also causes drowsiness to assist you get rest.

Mucinex and NyQuil Cold & Flu are only for world 12 years and older. However, NyQuil has various other products that are specifically made for kids periods 4 to 11 years.

The recommended dosage for each drug varies according to the develop. Follow the recommfinished dosage on the package of whatever create you pick. You will should ask your medical professional for the correct dosage of NyQuil to give to kids that are 4 to 11 years old.

Mucinex does not have the risk of major side results. However before, the adhering to significant side effects might be possible through NyQuil:

vision troubles, such as blurry visiondifficulty urinatingallergic reactivity, through symptoms such as:red, peeling or blistering skinrashhivesitchingswelling of the confront, throat, tongue, lips, eyes, hands, or lower legsdifficulty breapoint or swallowing

If you have actually major side impacts, you must soptimal using the drug and also contact your medical professional.


Drug interactions can increase or decrease the result of the various other medicines. Interactions deserve to also rise your hazard of side effects. Tbelow are no well-known considerable interactions through guaifenesin, the energetic ingredient in Mucinex. However, all three energetic ingredients of NyQuil communicate through various other drugs.

Acetaminophen have the right to connect with:

warfarinisoniazidcarbamazepine (Tegretol)phenobarbitalphenytoin (Dilantin)phenothiazines

Dextromethorphan deserve to communicate with:

isocarboxazidphenelzine (Nardil)selegilinetranylcypromine (Parnate)

Doxylamine have the right to communicate with:

isocarboxazidphenelzine selegilinetranylcyprominelinezolidopioids such as fentanyl, hydrocodone, methadone, and morphine

You shouldn’t use Mucinex or NyQuil to treat a permanent cough. Using too much can cause harmful results. You additionally shouldn’t use these commodities to treat symptoms of any kind of medical condition you have actually without talking to your doctor first.

Other conditions

Other problems you might have actually can affect how NyQuil works for you. In some conditions, this drug have the right to be harmful. Ask a medical professional before utilizing NyQuil if you have:

liver diseaseglaucomaurinating because of enlarged prostate gland


Don’t usage Mucinex or NyQuil for longer than seven days. If your symptoms aren’t relieved after a week, call your physician and stop making use of these drugs.

NyQuil has acetaminophen, which can reason significant liver damages if you overuse it. Taking even more than four doses of NyQuil in 24 hrs can reason serious liver damage. Many type of over-the-respond to drugs likewise contain acetaminophen. If you take NyQuil, make sure you don’t take it with various other drugs that contain acetaminophen. This will help make certain you don’t accidentally use too much of the drug.

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Mucinex and also NyQuil are both commodities that relieve symptoms of the widespread cold or flu. The symptoms they treat are different. You can take Mucinex and also NyQuil together safely if you follow the recommfinished dosage for each drug. However before, taking Mucinex at night with NyQuil can actually keep you from falling asleep. Mucinex will loosen your mucus, which deserve to cause you to wake as much as cough.

Deciding between the 2 may sindicate suppose choosing the drug that treats the symptoms that are bothering you the most. Of course, you need to never take any type of drug if you’re not certain exactly how to usage it or if it’s right for you. Almeans talk to your medical professional if you have actually inquiries.